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Generic name: Fluvoxamine
Brand name: Luvox

DRUGS Class and Mechanism: Fluvoxamine is a drug used to treat several psychiatric disorders. It is in a class of drugs called selective serotonin reuptake of serotonin (SSRIs), a class that also includes fluoxetine (Prozac) sertraline (Zoloft) and paroxetine (Paxil). inhibitors selective serotonin reuptake on neurotransmitters (chemicals) that nerves Use the brain to communicate. Many experts believe that the imbalance in these neurotransmitters is the cause of depression and other psychiatric disorders. Fluvoxamine acts inhibiting the reuptake of serotonin (a neurotransmitter) in nerve cells. Therefore, there is more serotonin available to stimulate other nerves in the brain. Fluvoxamine has been approved by the FDA for the treatment of obsessive-compulsive disorder in December 1994.

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PRESCRIPTION: Yes

Generic Available: Yes

Presentation: Tablets 25, 50, 100 mg.

STORAGE: Tablets should be stored at room temperature, 15-30 ° C (59-86 ° F).

Hint: Fluvoxamine is used to treat obsessive-compulsive disorder (OCD). However, like other SSRIs, has also been used in the treatment of major depression, the management of obesity, bulimia, schizophrenia and panic disorder.

Dosage: The usual starting dose for adults is 50 mg administered in a single dose in the morning. The dose may be increased by 50 mg increments every 4-7 days to get the desired response. The maximum dose is 300 mg / day. Doses higher 100 mg should be administered in divided doses.

Children (8-17 years) should begin with 25 mg per day and the dose may be increased by 25 mg every 4-7 days to a maximum of 200 mg / day. Doses above 50 mg should be administered in divided doses.

INTERACTIONS: All SSRIs, including fluvoxamine, should not be taken with a monoamine oxidase inhibitor (MAOI) class of antidepressants such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). These combinations can lead to confusion, hypertension, tremors and increased activity. Fluvoxamine should not be administered within 14 days after interrupting an MAO inhibitor. This same type of interaction can also occur with selegiline (Eldepryl), fenfluramine (Pondimin) and dexfenfluramine (Redux). Fluvoxamine may inhibit the clearance of clozapine (Clozaril) requiring a dose reduction of clozapine. Fluvoxamine may also inhibit the elimination and increase blood levels of theophylline (Theodur, UNIPHYL), warfarin (Coumadin), alprazolam (Xanax) and triazolam (Halcion).

Pregnancy: There are no studies Fluvoxamine appropriate in pregnant women.

Breastfeeding: Fluvoxamine is excreted in breast milk. There are no adequate studies lactating women.

SIDE EFFECTS: Side effects of all SSRIs include anxiety, nervousness, sweating, nausea, loss of appetite, constipation, diarrhea, dry mouth, somnolence (sleepiness), dizziness, insomnia and sexual dysfunction.

The withdrawal of an SSRI may lead to withdrawal symptoms. The most common symptoms of withdrawal are dizziness, fatigue, tingling of the extremities, nausea, abnormal dreams, irritability and mood swings. Other symptoms are visual disturbances and headaches. withdrawal reactions were reported after an average of 12-36 weeks of treatment, but after only five weeks. Although most authors recommend the discontinuation gradually reducing the dose, the symptoms may still occur. Symptoms usually appear within days of stopping the drug and persist for an average of 12 days (21 days). They get better within 24 hours to return to administer the drug was discontinued.

Antidepressants may increase the risk of suicide among children and adolescents. There are concerns that antidepressants may cause suicide in adults. Patients with severe depression may experience worsening depression or suicidal thoughts, irrespective of whether they are treated. By Therefore, patients started on antidepressants should be closely monitored for signs of worsening of suicidal thoughts or behavior change.

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